Medical Physiology : Principles for Clinical Medicine by Rhoades Rodney A. & Bell David R

Author:Rhoades, Rodney A. & Bell, David R.
Language: eng
Format: epub
Publisher: Wolters Kluwer Health
Published: 2017-06-20T16:00:00+00:00

GLOMERULAR FILTRATION

The filtration of plasma in the glomerulus is a process of bulk flow where water and low molecular weight substances move from the glomerular capillary across the filtration barrier and into the Bowman capsule. What is filtered is an ultrafiltrate. The term ultrafiltrate indicates that glomerular filtration barrier functions as a molecular sieve that allows filtration of small molecules but restricts the passage of macromolecules. The ultrafiltrate includes low molecular weight substances that are freely dissolved in plasma and includes various polar organic molecules such as glucose, amino acids, ions peptides, drugs, and waste products (e.g., creatinine and urea). Since filtration involves bulk flow, the concentration of the substance in the ultrafiltrate is the same as its concentration in the plasma. What are not filtered are blood cells, large proteins, and any small weight molecules that are bound to the large proteins.

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